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OBJECTIVE

目的

Combustible tobacco smoking leads to significant health deficits including reproductive morbidity. Paternal smoking has been shown to increase the risk of spontaneous abortion (SAB). Vaping may be a potentially safer alternative for nicotine consumption; however, limited studies exist evaluating paternal vaping. The current study evaluated the association between paternal vaping and SAB.

可燃烟草吸烟导致明显的健康损害，包括生殖疾病。男性吸烟已被证明会增加自然流产（SAB）的风险。电子烟可能是尼古丁的潜在更安全的替代品；然而，评估男性吸电子烟的研究有限。本研究评估了男性吸电子烟与自然流产之间的关系。

MATERIALS AND METHODS

材料和方法

We analyzed data from 1,446 males aged ≥21 years participating in Pregnancy Study Online (PRESTO), a preconception cohort study in North America of pregnancy planners. On baseline questionnaires completed during the preconception period, male participants and their female partners reported information about demographics, tobacco product use and other lifestyle characteristics. Female partners completed bimonthly follow-up questionnaires to update their data on pregnancy status and SAB. We used Cox regression models with multiple imputation to estimate hazard ratios (HRs) and 95% confidence intervals for the associations of ever use of nicotine vaping with SAB, while adjusting for male and female factors including cigarette smoking.

我们分析了1446名年龄≥21岁的男性数据，他们参加了妊娠研究在线（PRESTO），这是一项在北美进行的妊娠计划者的孕前队列研究。在孕前期间完成的基线问卷调查中，男性参与者及其女性伴侣报告了有关人口统计学，烟草产品使用和其他生活方式特征的信息。女性伴侣每两个月完成一次随访问卷，以更新其妊娠状态和自然流产数据。我们使用具有多重插补的Cox回归模型来估计曾经使用尼古丁电子烟与SAB之间的风险比（HRs）和95%的可信区间，同时调整了包括吸烟在内的男性和女性因素。

RESULTS

结果

The mean age for the males and females was 32 years and 30 years, respectively, with over 85% self-identifying as white. 72% of the cohort had completed college. 19% of males reported ever vaping, 10% reported current smoking, and 10% reported ever use of chewing tobacco. In all, there were 339 SABs. The prevalence of male ever vaping was 21% among the couples who experienced a SAB and 24% among the couples without a SAB. In multivariable models, male ever vaping was not materially associated with SAB (HR 1.05, 95% CI 0.77-1.43). In addition, no associations were apparent for male ever chewing tobacco, female ever vaping, or combinations of male and female ever vaping (i.e. M+P+, M+P-, M-P+,M-P-) with no patterns identified.

男性和女性的平均年龄分别为32岁和30岁，超过85%的参与者为白种人。72%的人完成了大学学业。19%的男性报告曾经吸过电子烟，10%报告当下有吸烟，10%报告曾经使用咀嚼烟草。总共有339例发生自然流产（SAB）。在经历过SAB的夫妇中，男性吸烟率为21%，在没有SAB的夫妇中为24%。在多变量模型中，曾经吸过电子烟的男性与SAB没有显著相关性（HR 1.05，95% CI 0.77-1.43）。此外，对于曾经咀嚼烟草的男性，曾经吸过电子烟的女性，或曾经吸过电子烟的男性和女性的组合（即男性和女性的组合）（例如M+P+、M+P-、M-P+、M-P-），均未发现与SAB存在显著相关性。

CONCLUSIONS

结论

The current report suggests that a history of paternal vaping is not associated with SAB.

目前的研究表明，男性吸电子烟史与SAB无关。

IMPACT STATEMENT

影响声明

While the current report did not find an association between a history of paternal vaping and pregnancy loss, further assessment of current vaping during preconception will be required to better assess safety.

虽然目前的研究没有发现男性吸电子烟与妊娠丢失之间的关联，但需要进一步评估孕前当下吸烟的影像情况，以更好地评估安全性。

文章来源：

THE ASSOCIATION BETWEEN A HISTORY OF PATERNAL VAPING AND SPONTANEOUS ABORTION Eisenberg, Michael et al.Fertility and Sterility, Volume 118, Issue 4, e305 - e306

Tags： 男性吸电子烟与自然流产之间无关？