STUDY QUESTION

研究问题

In women undergoing fertility treatment, do those with polycystic ovary syndrome (PCOS) have a higher prevalence of symptoms of anxiety and depression and lower body appreciation than women without PCOS?

在接受生育治疗的女性中，多囊卵巢综合征（PCOS）患者是否比非PCOS患者更容易出现焦虑、抑郁，并且对自己的身体更不满意？

SUMMARY ANSWER

总结回答

Having PCOS was not associated with symptoms of anxiety and depression but was associated with somewhat lower body appreciation.

患有PCOS与有焦虑、抑郁的症状无关，但与较低的身体形象欣赏力有关。

WHAT IS KNOWN ALREADY

已知信息

PCOS has been associated with a higher chance to develop mental health problems, like anxiety, and body image concerns. The International Guidelines on PCOS recommend that all women with PCOS should routinely be screened for anxiety and depressive disorders. In most studies in this field, the comparison group included healthy women without fertility problems.

PCOS被认为更有可能出现心理健康问题，如焦虑和身体形象的担忧。PCOS国际循证指南建议所有PCOS女性都应定期接受焦虑和抑郁障碍筛查。在该领域的大多数研究中，对照组纳入了没有生育问题的健康女性。

STUDY DESIGN, SIZE, DURATION

研究设计，规模，持续时间

We conducted a cross-pal survey study between May 2021 and July 2023, using an online questionnaire. We informed women about this study at fertility clinics in the Netherlands through posters and leaflets and on the websites of the Dutch patient organizations Freya and Stichting PCOS.

我们在2021年5月至2023年7月期间采用在线问卷的形式进行了一项横断面研究。通过海报、传单以及荷兰患者组织 Freya 和 Stichting PCOS 的网站向荷兰不孕不育诊所的女性介绍了这项研究。

PARTICIPANTS/MATERIALS, SETTING, METHODS

研究对象/材料，背景，方法

This study included women with infertility, with and without PCOS, who were undergoing fertility treatment. Women completed two assessment tools: the Hospital Anxiety and Depression Scale (HADS) and the Body Appreciation Scale-2 (BAS-2). Primary outcomes were clinically relevant symptoms of anxiety (score≥11) and depression (score≥11), and BAS-2 scores. Secondary outcomes were mean anxiety and depression scores and anxiety and depression scores of 8 and higher. Dichotomous outcomes and continuous outcomes were analysed using logistic and linear regression analyses adjusted for age, BMI, and duration of infertility.

本研究纳入了接受生育治疗的PCOS和非PCOS不孕女性。研究对象填写两份评估量表：医院焦虑抑郁量表（HADS）和身体鉴赏量表-2（BAS-2）。主要结果为临床相关的焦虑症状（评分≥11分）、抑郁症状（评分≥11分）和BAS-2评分。次要结果为焦虑和抑郁的平均得分、焦虑和抑郁的8分及以上得分。采用逻辑和线性回归分析法对二分结果混合连续结果进行分析，并对年龄、体质指数和不孕年限进行调整。

MAIN RESULTS AND THE ROLE OF CHANCE

主要结果和机会的作用

A total of 1025 women currently undergoing infertility treatment participated, of whom 502 (49.0%) had PCOS and 523 (51.0%) had other infertility diagnoses. We found self-reported clinically relevant symptoms of anxiety in 33.1% of women with PCOS and in 31.0% of women with other infertility diagnoses (adjusted OR: 0.99, 95% CI 0.74–1.31). Clinically relevant symptoms of depression were reported in 15.5% of women with PCOS versus 14.5% of women with other infertility diagnoses (adjusted OR: 1.04, 95% CI 0.71–1.50). Women with PCOS reported slightly less body appreciation (adjusted mean difference: −1.34, 95% CI −2.32 to −0.36).

参与研究的总共有1025名正在接受不孕症治疗的妇女，其中502名（49.0%）被诊断为多囊卵巢综合征（PCOS），523名（51.0%）被诊断为其他不孕症。我们发现，自我报告的临床相关的焦虑症状在PCOS患者中占33.1%，其他不孕症患者中占31.0%（调整后的OR：0.99，95% CI 0.74-1.31）。临床相关的抑郁症状在PCOS患者中占15.5%，其他不孕症患者中占14.5%（调整后的OR：1.04，95% CI 0.71-1.50）。PCOS患者报告的身体欣赏程度稍低（调整后的平均差异：-1.34，95% CI -2.32 to -0.36）

LIMITATIONS, REASONS FOR CAUTION

局限性，谨慎的理由

Results are based on self-report and may have been affected by sampling bias.

研究结果是基于自我报告产生的，而且可能受到抽样偏差的影响。

WIDER IMPLICATIONS OF THE FINDINGS 

研究结果更广泛的意义

Although guidelines recommend screening women with PCOS, feelings of anxiety and depression can be present in any woman undergoing fertility treatments. We advise fertility clinics to be aware of women’s mental health issues and to offer support accordingly, as a part of routine care.

尽管指南建议对PCOS女性进行筛查，但任何接受生育治疗的女性都会出现焦虑和抑郁的感觉。我们建议生育诊所注意女性的心理健康问题，并作为常规护理的一部分提供相应的支持。

参考文献：

T Jannink, E M Bordewijk, J Aalberts, J Hendriks, V Lehmann, A Hoek, M Goddijn, M van Wely, ANDES study group , Anxiety, depression, and body image among infertile women with and without polycystic ovary syndrome, Human Reproduction, Volume 39, Issue 4, April 2024, Pages 784–791, https://doi.org/10.1093/humrep/deae016

Tags： 焦虑、抑郁和身体形象在PCOS和非PCOS不孕妇女中的研究！